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In certain embodiments, R 7a is substituted or unsubstituted phenyl. For example, chloroquine derived from quinine anhydrotetracycline has been demonstrated to efficiently repress transcription in prokaryotic organisms in the range of about 50-fold (eg, see FIG.

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Do feel more tired then usual but that is when I do not get 8 hour sleep which I know I need to be fresh?

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